Mammalian Toxicology surveys chemical agents and examineshow such chemicals impact on human health, emphasizing theimportance in minimizing environmental exposure to chemical andphysical hazards in our homes, communities and workplaces throughsuch media as contaminated water, soil and air.Starting with the basic principles on a wide range of toxicagents, this textbook describes how they enter the body, theirmechanisms of action once inside, and strategies for diagnosis,prevention and treatment.Topics covered include:General principles of toxicology: pharmacological andtoxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell deathDisposition: routes of chemical exposures, entry intothe body and various tissues, storage, metabolic biotransformationand elimination, with examples from various toxicants.Toxic agents: the occurrences, disposition in the body,health effects, toxic mechanisms, antidotes and treatments of arange of agents including pesticides, metals, solvents, gases,nanomaterials, food components and additives, pharmaceuticals,drugs of abuse, natural toxins, endocrine disruptors, radiation,and warfare weapons. Toxic effects: including neurotoxicity, developmentaltoxicity, immunotoxicity, teratogenecity, male and femalereproductive toxicity, mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity,gastrointestinal toxicity and cardiovascular toxicityToxicology and society: epidemiological studies ofchemical-induced diseases in human populations, and a vision fortoxicology in the 21st century.Mammalian Toxicology is an essential primer for studentsof toxicology, biochemistry, biology, medicine and chemistry. It isalso appropriate for professional toxicologists in research orregulatory affairs, and anyone who needs to understand the adverseeffects of toxic agents on the human body.
- 2015 Wiley
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